Is this drug safe?
Let’s talk about the Therapeutic Index of psilocybin.
Almost 500 years ago to the Swiss physician (and Boss Man) Paracelsus wrote
“The right dose differentiates a poison from a remedy.”
The therapeutic index is a measure of the safety and effectiveness of a medication. It compares the amount of drug needed to produce a desired therapeutic effect to the amount of drug that can cause harmful side effects.
A higher therapeutic index means the drug is safer and more effective, while a lower therapeutic index means the drug is riskier and less effective.
The therapeutic index is calculated by dividing the median lethal dose (LD50) of a drug by the median effective dose (ED50) of the same drug.
** The median lethal dose (LD50) of a drug is the dose at which 50% of the test population dies from - while the median effective (ED50) dose is The dose of a medication that produces a specified effect in 50% of recipients.These values are typically determined through animal testing and are used to determine appropriate dosages for human use.
The resulting number (dividing LD50 by ED50) indicates the range between the dose that produces therapeutic effects and the dose that causes toxic effects.
A larger therapeutic index means it is safer to use the drug. The HIGER the number, the safer the drug- with a much wider potential for multiple conditions.
So, for example, if a drug has an LD50 of 100mg and an ED50 of 20mg, the therapeutic index would be 5
100/20= 5.
A therapeutic index of 1 means that the drug is equally as likely to produce therapeutic effects as it is to produce toxic effects. This is dangerous stuff. No bueno.
The Registry of Toxic Effects of Chemical Substances assigns psilocybin a high therapeutic index of 641; for comparison, the therapeutic index of Zoloft is 141 .
(The Registry of Toxic Effects of Chemical Substances (RTECS) is a database of toxicological information compiled, maintained, and updated by The National Instituteo for Occupational Saftey & Health).
What is the Lethal Dose of shrooms tho?
Remember the LD50 - the median lethal dose is the dose at which 50% of the test population dies from - and the test population for shrooms being rats and rabbits.
In rats, psilocybin the median lethal dose (LD50) when administered orally is 280 milligrams per kilogram (mg/kg), approximately one and a half times that of caffeine.
When administered intravenously in rabbits, psilocybin's LD50 is approximately 12.5 mg/kg.
On average Psilocybin comprises approximately 1% of the weight of Psilocybe cubensis mushrooms. This means nearly 3.7 lbs of dried mushrooms, or 37 lbs of fresh mushrooms, would be required for a 130 lb person to reach the 280 mg/kg LD50 value of rats.
37 pounds of mushrooms to reach the LD50 of rats…
That’s the weight of a full grown 4 year old (a whole ass kindergartener).
Just sayin,
G
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